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amoeba, August 18,  2020  12:01pm EST

Vitamin B3 derivative NR raises N.A.D.+ levels and lowers inflammation in stage D heart failure patients

This is the first of two heart failure/NR studies that have been expected to come out this summer or fall from the University of Washington. 19 Stage D heart failure patients took 2,000 mg of Nicotinamide Riboside (NR) for 5 to 9 days as did 19 healthy people. NR boosted N.A.D.+, which decreases through age and is reducede in those in heart failure, and in doing so reduced inflamation. Here are some quotes from the study and the prress release:

"In this study we aimed to investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effect of boosting N.A.D.+ level.  

"PBMCs have been implicated in the inflammatory response that leads to the decompensation and worsening of heart failure. Mitochondrial health of PBMCs, as evidenced by the respiration rate, could be the culprit and reporter of the inflammatory process.

"By increasing the mitochondrial health of PBMCs, proinflammatory cytokine production was reduced. These findings further support an important role NR may have in a variety of cardiovascular-related health declines."

"We found that increasing N.A.D+ levels with nicotinamide riboside (NR) suppressed inflammatory activation in end-stage heart failure patients,"

5 Replies
  • AHAASAKatie
    AHAASAKatie, August 19,  2020  9:04am EST

    Thank you for sharing this study. It does raise some interesting points. Is this a treatment option you are discussing with your doctor? Thanks Katie

  • amoeba
    amoeba, August 19,  2020  4:57pm EST

    I have told my doctor about NR (Niagen) and have even sometimes brought in the bottle since late 2016 when I first started to take it. He just nods, and I keep taking my meds along with 5 supplements. I talked to my nurse practioner about it two weeks ago and said a heart failure study should be out by the end of summer and then added that if the results are good, he will know. It looks like this is the first part of the study and I assume there will be a second part (publication) that reveals how the heart failure patients with an EF under 40 fared after 12 weeks at 2,000 mg a day, split between morning and evening.  

  • JamesPL
    JamesPL, August 19,  2020  7:59pm EST

    Thanks for sharing. I find it encouraging that we continuously see these kinds of studies. Offers much hope for heart patients. 


  • JT1972
    JT1972, August 23,  2020  11:04pm EST

    Ok, I’m new here, my husband has had congestive heart failure since “98”, he had an aortic dissection in”07”, he will be 48 in November.

    His device has shocked him since July of this year, the last date was the 19th of this month and he just got out of the hospital yesterday ( August 23rd). His heart has been pumping at 12% for at least the last year. This last hospital stay, the doctor said his heart is very very weak and he needs to see a doctor in Cleveland for an LVAD monitor. We are both very scared and very depressed, we knew this day would come but we’re not ready for this chapter in our lives. What if his heart is so weak that he can’t get the LVAD? I feel helpless and depressed and he has been sleeping all day today. I don’t know what I’m gonna do without him and I don’t want to be here without him. I need some advice

  • MrtnslvMSME
    MrtnslvMSME, August 25,  2020  10:45am EST

    @JT1972 Have you considered giving Metabolic Cardiology a try? 

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