amoeba
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amoeba, February 11,  2019  1:13pm EST

University of Washington NR study on heart failure results postponed?

It looks like the results of the Universty of Washington trial of heart failure patients taking 2000 mg of NR, a vitamin B3 derivative sold as Niagen, may not be published untl late next year according to the updated website linked to below. Then again, leading NR researcher Charles Brenner at Iowa State said a few months ago that he knows the results but can't discuss them yet.

However, another study released a couple of weeks ago showed that ALS (Lou Gherig's disease) patients who took 600 mg of NR with 100 mg of pterostilbine (found in blueberries) actually improved the patients scores by 5 points on a 48 point subjective scale. In comparison, the best ALS drug approved two years ago only delayed the health slide by 33%. To me, this is good evidence that NR will help heart failure patients as it clearly did in mice but of course we don't know by how much.

Elysium, a company that sells Basis, a combination of NR and pterostilbine, supplied the supplement for the trial, but it is likely that NR, which boosts NAD+ in cells, was the important molecule. 

https://www.tandfonline.com/doi/abs/10.1080/21678421.2018.1536152?journalCode=iafd20

https://clinicaltrials.gov/ct2/show/NCT03423342

5 Replies
  • JamesPL
    JamesPL, February 11,  2019  8:05pm EST

    Thanks for sharing. Sounds very promising. This is why it's important to contribute to various organizations that help to support these studies. It's a long, slow process but every once in awhile we have a breakthrough that benefits so many people!

    Lets' hope for another success!

    Jim

  • JoeSzzz
    JoeSzzz, February 15,  2019  5:44pm EST

    Hello!

         I have had heart failure for the past 10-15 years. I take massive amounts of ubiquinol. I have been good for the past  10 -15 years - eventhough I have had "events" that would scare anyone. I used to go to the ER. I would run up big bills. I no longer do that after taking 1 gram of ubiquinol every 30 minutes unti about 2 bottles are gone. This has been great. I still lift weights and excersice, with very little shortness of breath adn ankle swelling comes and goes. How ever I am really treating the underlying problem....age. Your body is just wearing out! I have now - just last week - starting to take HGH to repair my heart and other organs. HGH reaches it's peak when you are in your 20s. You have to be careful, because as you age, you can grow some "bad stuff" in your body. When your body was young, you had young materials and very few defects, as you get older - drinking, bad eating, pollution, other harmful agents , take a toll on your body. So you have to be careful while taking HGH. HGH is mostly offered to the affluent because they have the money to pay for the high price of HGH. You might be able to get it through your insurance company. The stuff used to be cheap....a long time ago. Massive amounts of ubiquinol and HGH. I hope this helps!

  • amoeba
    amoeba, February 17,  2019  10:41am EST

    NR (nicotnamide riboside) is a vitamin B3 dervative found in trace amounts of milk, bananas, edamame and a few other beans. I'm not sure about HGH but NR has been shown to raise a person's NAD+ levels that all cells need to be healthy and reverse that one aspect of aging a bit. As University of Iowa NR expert Charles Brenner explained, all failing hearts lack normal amounts of NAD+ so the failing heart "wants" NR that comes near it which converts to NAD+. (Too much alcohol and sun exposure will temporaily lower NAD+ levels, even among those with healthy hearts.) 

    250 mg of NR ($1 a day) has been shown to raise NAD+ by 40% in the blood whereas 500 mg ($2 a day) will raise NAD+ 90% in the first month before that falls down to around 50% by the end of the second month. I can see why the Unversity of Washington trial ramps up to 2,000 mg a day (demonstrated to be safe) since the hope is that the failing heart will get a lot of NR to convert to NAD+.

    There is also one start-up company that says it has enhanced NR so that NAD+ levels stay above 100% the old baseline instead of dropping down to 50% the previous baseline. I think others like Tru Niagen and Elysium are trying to do the same thing so something to watch for this year. 

     

  • CBrenner
    CBrenner, February 26,  2019  12:29pm EST

    This is Charles Brenner. I am not at Iowa State and I never said that I know the results of a heart failure study at the University of Washington. The UW team consists of very reputable researchers and the study is well justified on the basis of preclinical research that we and others have done. I am looking forward to the results just as everyone else in the heart failure community is.

    As for Elysium supplying materials for another clinical trial of NR, that is rather shocking since they have do not hold the license on the key intellectual property on using NR to boost NAD metabolism either for nutritional or therapeutic applications. In fact, they tried unsuccessfully to invalidate the Dartmouth intellectual property. This is a matter of public record.

    I'm not a blogger but a busy research scientist, so this is the last I will be contributing to this forum.

    Best,

    Charles Brenner, PhD

    University of Iowa

  • amoeba
    amoeba, March 1,  2019  7:14am EST

    This is the February 23rd, 2017 podcast I was refering to:

    Charles Brenner at 35:30: "There have been some trials that have been intiated for type 2 diabetes and heart failure, but we can't talk about results yet. There are addtional trrals whose results are going to be made public in coming months that say some important things about common condtions that occur in Western populations."  

    http://www.llamapodcast.com/charles-brenner/

     

     

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