• 19 replies
  • 6 followings
MellanieSAF, March 28,  2021  3:12pm EST

Important research for competitive athletes and extreme exercisers

Extreme Exercise Carries Metabolic Consequences: Study
-- Healthy people put through high-intensity interval training, or HIIT, displayed insulin resistance and mitochondrial dysfunction after working out excessively.


  • jwm1776
    jwm1776, March 28,  2021  3:47pm EST

    I see a couple of problems here.  Very low sample size and an in dividual doesn't go from working out for 2 weeks to high intensity workouts.  It takes 10 days to increase muscle mass and then the subjects were thrown into high intensity workouts.  I'd like to see what the result had been if the sublects were allowed to reach a high level of conditioning based on their own timeline that doesn't require high intensity workouts starting at week 3.

    And how many of us get enough exercise anyway?  Obesity is probably the #1 cause of health problems in the US.

  • MellanieSAF
    MellanieSAF, March 28,  2021  3:53pm EST

    Agreed - most people do not get enough exercise.

    However, we know without a doubt, through so much research, that excessive exercise greatly increases the risk for developing afib.

    This study had a compressed time frame, but that does not negate these findings showing that excessive exercise is correlated with insulin resistance and mitochondrial dysfunction.


  • jwm1776
    jwm1776, March 28,  2021  4:55pm EST

    The number of people that actually reach that point of "too much evercise" is infintesimal compared to those who are obese. 

  • depotdoug
    depotdoug, March 28,  2021  5:08pm EST

    Agreed with obese peoples and heart issues.

    I should not comment on exercise yet. I am still 4 whole days from full scale exercising. Yes, my 30 days post RA Lead revision March 1st. Or after my 2nd Pfizer/Biotech Vax jab tomorrow 11:30.  We will see if or went or not my Vax delivers SE's.


  • MellanieSAF
    MellanieSAF, March 28,  2021  5:10pm EST

    While that statement is true, we have a disproportionate number of people in the various afib forums who are athletes with afib. That is why I posted this specific article. This is a topic of frequent discussion.

    This research was not posted to offend anyone but instead to inform because it is such an important topic here.


  • jwm1776
    jwm1776, March 28,  2021  5:19pm EST

    Sorry, as someone who has spent a significant portion of their life evaluating research 11 people is too small a sample size and the way these individuals were forced into high intensity workouts tells me the researchers set up the experiment to get the results they desired.  If the research had 100+ people and they were guided into cardiovascular and muscular shape over a 6 week period then the results would be more informative.


  • MellanieSAF
    MellanieSAF, March 28,  2021  5:36pm EST

    It really depends on the kind of study. This is just experimental research to evaluate a concept; it's not like a pharma safety and efficacy study that requires thousands of people. This kind of proof of concept research typically involves just small numbers of people (getting funding for larger studies is so much harder, especially related to exercise when there is no one with a vested interest in funding it). The number of participants in many procedure studies that are proof of concept studies is often just 20-30, so this is not that different. And, it's not about improving cardiovascular health overall - it's about identifying what might happen from overdoing things. 


  • jwm1776
    jwm1776, March 28,  2021  9:25pm EST

     "This is just experimental research to evaluate a concept; it's not like a pharma safety and efficacy study that requires thousands of people."

    So true, however your opinion carries more influence on this site than other members.  People look at something you post and give it far more consideration if it was posted by another member.  So, perhaps it would be wise to refrain from posting material posing as a scientific study when in reality the sample size and design of the study render any results virtually meaningless.

    Have a great evening!



  • Thumper2
    Thumper2, March 29,  2021  9:06am EST

    jwm1776, I read the study to which Mellanie refers and found it interesting.  The discussion of various points of view within the study makes it clear that it is not "posing as a scientific study."  It describes itself as a limited study, with limited goals and results.   I'm glad Mellanie did not "refrain from posting" it.  This limited study could be of value to those who have gotten AFib and wonder what caused it, since they are such good exercisers.  There's no definitive answer in the study, but the results could be suggestive.  I think most of us here wonder why we got AFib -- I know I do (and I know it's not from extreme exercising!).   This is an ongoing question, and studies such as this one can add to our thoughts on the matter.

    Thumper2 (Judy)

  • MellanieSAF
    MellanieSAF, March 29,  2021  11:07am EST


    It's a single data point, and needs to be replicated with more and larger studies. But, it's an important data point that those who do extreme exercise will likely want to be aware of as a possible concern. 

    Can you share with us why you have taken offense to this study and where you're coming? 


dark overlay when lightbox active
dark overlay when lightbox active
dark overlay when lightbox active
dark overlay when lightbox active