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msa508, January 5,  2019  9:09pm EST

PSK9 questions

is anyone using these and having any side effects ? Repatha or Praudulent? And my question is why with drastic lower numbers why is it only a 20 percent chance to stop heart attacks ?

5 Replies
  • yarn007
    yarn007, January 7,  2019  2:11am EST

    Welcome to the site MSA508!   Must admit I am not taking either of the drugs that you mentioned, but I am sure someone on here might have some thoughts on your question.   Just wanted to say "Hi".    Hope all is well with you.

    Thanks for joining us.

  • JamesPL
    JamesPL, January 7,  2019  1:08pm EST

    I am not taking any of these drugs either but I think when it comes to heart disease, there aren't any sure fire preventatives. The drugs supplement all other life style changes which should include a healthy diet and exercise. There are no guarantees but doing these things should greatly reduce your risk. The statin drugs I'm on reduced my cholesterol by 100 points. I don't think this prevents me from having a heart attack but it helps to reduce the risk which is the goal.


  • BartO
    BartO, January 19,  2019  8:29am EST

    Cholesterol is found in large amounts in all animal foods. When people eat meat, poultry, fish, eggs, and dairy products their blood cholesterol levels rise. The rationale is that lowering these levels with medication will fix the problem. The real-life benefits have been minimal this failure has led researchers to look into other mechanisms to explain how eating animal products and other unhealthy foods cause artery damage. Meat, dairy products, eggs, and other animal foods favor the growth of bacteria that readily convert carnitine and choline to TMA. Vegans and vegetarians grow few of these kinds of bacteria and as a result produce very little artery-damaging TMAO. Starches, vegetables, and fruits are essentially cholesterol-free and discourage the growth of intestinal bacteria that lead to the synthesis of artery-damaging TMAO; and these foods contain very little carnitine and choline (the precursors of TMAO). Unarguably,—whether blaming cholesterol, carnitine, choline, or bad-bowel-bacteria—diseases of atherosclerosis (heart attacks, strokes, kidney failure, etc.) are due to consuming meat, dairy products, and eggs. To prevent and treat heart and other artery diseases fix the problem if you eat meat, dairy products, eggs, and other unhealthy foods then you will benefit from taking statins (a little). Eat a whole food plant based diet and any benefits from statins for an otherwise healthy person vanish, and all that is left are side effects and costs. For most people with a history of heart surgery, heart disease, TIAs, or stroke, in addition to a plant based diet you may also need sufficient cholesterol-lowering statin medications to lower your blood cholesterol to 150 mg/dL or less.


  • DolphinWrite
    DolphinWrite, February 9,  2019  1:16am EST

    Medicines are designed to give you the best hope for improved health, but they can't do everything much as wr'd like.  You still have the heart condition.  But with medicines and the right steps, improvements should come.  Patience is what we heart patients learn


  • EMON1
    EMON1, February 21,  2019  11:03pm EST

    EVERYTHING comes down to 'reducing' risks. Even the healthiest people often 'drop' suddenly. I suppose the trick is not focusing on things you can't control.

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